Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 101 to 125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
268 morphological change sperm (CL:0000019) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
646 morphological change extracellular matrix (GO:0031012) 1195: modulation, Extracellular Matrix Composition
223 morphological change anatomical structure morphogenesis (GO:0009653) 1001: Increased, Developmental Defects
981 morphological change abnormal excitatory postsynaptic current amplitude (MP:0011267) dendritic spine membrane (GO:0032591) 388: Overactivation, NMDARs
105 morphological change abnormal cardiovascular system physiology (MP:0001544) 317: Altered, Cardiovascular development/function
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
70 increased suppression of host defenses (GO:0044414) immune system (UBERON:0002405) 403: Suppression, Immune system
71 increased Disease Susceptibility (MESH:D004198) 323: Increased, Disease susceptibility
145 increased heme oxidation (GO:0006788) 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
147 increased hemolysis (MESH:D006461) 250: Damaging, Red blood cells; hemolysis
149 increased hemoglobin binding (GO:0030492) 118: Formation, Formation of hemoglobin adducts
151 increased erythrocyte (CL:0000232)
152 increased liver vascular congestion (MP:0010019) 246: Increase, RBC congestion in liver
153 increased hemosiderosis (MESH:D006486) 161: Increase, Liver and splenic hemosiderosis
243 increased gene expression (GO:0010467) cytochrome P450 1A1 (PR:000006101) 80: Up Regulation, CYP1A1
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP