Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 101 to 125 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


619	increased		cough (MESH:D003371)	2 Events 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea 1226: Increased Respiratory irritability and Chronic Cough,
557	increased	hyperplasia (MESH:D006965)	glandular epithelial cell (CL:0000150)	2 Events 1069: Increased, Hyperplasia (glandular epithelial cells of endometrium) 772: Increase, Hyperplasia (glandular epithelial cells of endometrium)
887	increased	gene expression (GO:0010467)		2 Events 2021: Increase, slincR expression 2199: Increased, Expression of LXR activated genes
109	decreased	egg quantity (VT:1000294)		2 Events 78: Reduction, Cumulative fecundity and spawning 972: Decreased fertility, Reduced number of oocytes ovulated
863	increased	chromosomal instability (MP:0008866)	chromosome (GO:0005694)	2 Events 1669: Increased, DNA damage and mutation 1896: Genomic instability
860	increased	DNA damage response, detection of DNA damage (GO:0042769)	site of DNA damage (GO:0090734)	2 Events 2006: Secondary genotoxicity 1669: Increased, DNA damage and mutation
943	increased	acute-phase response (GO:0006953)	Acute phase proteins (N/A)	2 Events 1438: Transcription of genes encoding acute phase proteins, Increased 1439: Systemic acute phase response
114	decreased		Luteinizing hormone (CHEBI:81568)	2 Events 129: Reduction, Gonadotropins, circulating concentrations 690: Reduced, Luteinizing hormone (LH), plasma
888	decreased	gene expression (GO:0010467)		2 Events 2020: Decrease, sox9 expression 2214: Decreased, Insulin-like peptide 3 (INSL3)
12	increased	ecdysone receptor-mediated signaling pathway (GO:0035076)	ecdysone receptor holocomplex (GO:0008230)	103: Increase, Ecdysone receptor hyperactivation
25	decreased	receptor transactivation (GO:0035624)	peroxisome proliferator-activated receptor alpha (PR:000013056)	858: Decreased, PPARalpha transactivation of gene expression
28	abnormal	abnormal lipid homeostasis (MP:0002118)		862: Not Increased, Circulating Ketone Bodies
29	abnormal		ketone body (CHEBI:73693)	862: Not Increased, Circulating Ketone Bodies
55	decreased	gene expression (GO:0010467)	brain-derived neurotrophic factor (PR:000004716)	381: Reduced levels of BDNF
58	increased	neurodegeneration (MP:0002229)		352: N/A, Neurodegeneration
59	decreased	learning (GO:0007612)		341: Impairment, Learning and memory
60	abnormal	dendrite morphogenesis (GO:0048813)	dendrite (GO:0030425)	382: Aberrant, Dendritic morphology
113	decreased	oocyte development (GO:0048599)		309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
115	decreased		Follicle stimulating hormone (CHEBI:81569)	129: Reduction, Gonadotropins, circulating concentrations
1147	increased	protein oxidation (GO:0018158)		1767: Increase, Protein oxidation
118	disrupted		mitochondrial respiratory chain (GO:0005746)	178: Mitochondrial electron transport chain, disrupted
120	increased	reactive oxygen species biosynthetic process (GO:1903409)	reactive oxygen species (CHEBI:26523)	1115: Increase, Reactive oxygen species
121	decreased		nitric oxide (CHEBI:16480)	193: Decreased, Nitric Oxide
122	decreased	long-term synaptic potentiation (GO:0060291)		166: Decreased, Long-term potentiation (LTP)
124	decreased	transport (GO:0006810)	bile salt export pump (PR:000003549)	41: Inhibition, Bile Salt Export Pump (ABCB11)