Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 101 to 125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway
40 increased excretion (GO:0007588) Tetrahydroaldosterone-3-glucuronide (CHEBI:88728) 401: Increase, Biliary excretion TH glucuronide
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
1028 increased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347) 2272: Testosterone levels, increased
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
94 decreased testosterone (CHEBI:17347)
389 decreased receptor binding (GO:0005102) testosterone (CHEBI:17347) 743: Decreased, Testosterone binding to androgen receptor (hypothalamus)
723 increased Testicular atrophy (HP:0000029) Testis (FMA:7210) 1506: Testicular atrophy
704 decreased testicular atrophy (MP:0003205) Testis (FMA:7210) None
963 increased Abnormality of the testis (HP:0000035) Testis (FMA:7210) 2206: Increased, histomorphological alteration of testis
728 increased gene expression (GO:0010467) teratocarcinoma-derived growth factor 1 (PR:000030513) None
1054 occurrence T cell migration (GO:0072678) T cell (CL:0000084) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
203 increased T cell activation (GO:0042110) T cell (CL:0000084) 272: Activation/Proliferation, T-cells
1041 increased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) None
1042 increased T cell migration (GO:0072678) T cell (CL:0000084) None
1057 occurrence T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 2260: Gluten-reactive CD4+ T cells, activation
62 decreased synapse assembly (GO:0007416) synapse (GO:0045202) 385: Decrease of synaptogenesis
984 disrupted synapse (GO:0045202) 2005: Altered neurotransmission in development
708 abnormal chemical synaptic transmission (GO:0007268) synapse (GO:0045202) 758: Hippocampal Physiology, Altered
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
919 increased respiratory electron transport chain (GO:0022904) superoxide (CHEBI:18421) 2120: Superoxide generation, increased
917 decreased FAD metabolic process (GO:0046443) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
918 decreased succinate metabolic process (GO:0006105) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
617 increased neuropeptide hormone activity (GO:0005184) Substance P (CHEBI:80308) 1222: SP (Substance P) release, Local increase of SP