Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 101 to 125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
172 increased SREBP signaling pathway (GO:0032933) sterol regulatory element-binding protein 1 (PR:000015611)
374 decreased spindle organization (GO:0007051) spindle (GO:0005819) 721: Disorganization, Meiotic Spindle
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
969 increased specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
972 abnormal specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
1013 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) sodium:potassium-exchanging ATPase complex (GO:0005890) 1562: Decreased Na/K ATPase activity
987 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) None
235 decreased sodium:iodide symporter activity (GO:0008507) sodium/iodide cotransporter (PR:000015171) 424: Inhibition, Na+/I- symporter (NIS)
1016 decreased sodium ion import (GO:0097369) gill (UBERON:0002535) 2236: Decreased, Sodium uptake in gills
325 decreased sodium channel inhibitor activity (GO:0019871) sodium channel protein type 1 subunit alpha (PR:000002095)
986 functional change sodium channel activity (GO:0005272) voltage-gated sodium channel complex (GO:0001518) 1977: Disruption of sodium channel gating kinetics
171 increased signaling (GO:0023052) carbohydrate-responsive element-binding protein (PR:000010460) 66: Activation, ChREBP
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
923 decreased signaling (GO:0023052) neurotransmitter (CHEBI:25512) 2151: Disruption, neurotransmitter release
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway