Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 126 to 150 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1048 increased increased circulating LDL cholesterol level (MP:0000182) low-density lipoprotein cholesterol (CHEBI:47774) 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
1049 increased increased circulating total protein level (MP:0005568) proprotein convertase subtilisin/kexin type 9 (PR:000012440) 2276: Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9)
1066 increased hormone activity (GO:0005179) None
1067 increased hormone activity (GO:0005179) tissue (UBERON:0000479) None
1073 increased aryl hydrocarbon receptor binding (GO:0017162) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1076 increased increased serotonin level (MP:0010069) extracellular region (GO:0005576) 1320: Increased, extracellular serotonin
1077 increased increased serotonin level (MP:0010069) serotonin (CHEBI:28790) 1320: Increased, extracellular serotonin
1078 increased serotonin receptor signaling pathway (GO:0007210) Serotonin receptor (FMA:67372) None
1080 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 1A (PR:000001161) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1081 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 2C (PR:000001168) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1082 increased estradiol secretion (GO:0035938) Glandular part of endometrium (FMA:86488) 2251: Estradiol availability, increased
1083 increased aromatase activity (GO:0070330) aromatase (PR:000006100) 2293: Aromatase, induction
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions
1089 increased Pulmonary edema (HP:0100598) lung (UBERON:0002048) 2316: Increased, pulmonary edema
1091 increased cell death (GO:0008219) cell (GO:0005623) 1825: Increase, Cell death
1095 increased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) 2041: Decrease, facial prominence outgrowth
1096 increased palatal shelves fail to meet at midline (MP:0009888) secondary palate (UBERON:0001716) 2041: Decrease, facial prominence outgrowth
1099 increased abnormal long term potentiation (MP:0002207) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1100 increased NMDA glutamate receptor activity (GO:0004972) None
1102 increased regulation of actin-dependent ATPase activity (GO:1904621) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1103 increased homeobox protein SIX1 (PR:000014896) None
1104 increased increased synaptic depression (MP:0002916) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1105 increased receptor agonist activity (GO:0048018) estrogen receptor (PR:000007204) 111: Agonism, Estrogen receptor