Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 126 to 150 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
638 increased signaling (GO:0023052) estrogen receptor (PR:000007204) None
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
655 increased signaling (GO:0023052) juvenile hormone (CHEBI:24943) 1205: Activation, Juvenile hormone receptor
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
668 increased signaling (GO:0023052) map kinase p38 (PR:000003106) 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
669 increased signaling (GO:0023052) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 1280: Activation, HIF-1
671 increased signaling (GO:0023052) Janus kinase (PR:000025748) 1282: Activation, JAK/STAT pathway
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway
681 increased signaling (GO:0023052) JNK Mitogen-Activated Protein Kinases (MESH:D048031) 1292: Activation, JNK
682 increased signaling (GO:0023052) forkhead box protein O (Caenorhabditis elegans) (PR:O16850) 1293: Activation, FOXO
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
305 abnormal signaling (GO:0023052) calmodulin (PR:000004978) 1243: Altered, Ca2+-calmodulin activated signal transduction
358 decreased signaling (GO:0023052) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte