Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1107 increased Metaplasia (MESH:D008679) Squamous cell (FMA:66769)
1108 increased Endometrial carcinoma (HP:0012114) adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
1109 increased Metaplasia (MESH:D008679) endometrium epithelium (UBERON:0004811) 1068: Endometrial squamous metaplasia, Increase
1111 increased translation (GO:0006412) homeobox protein SIX1 (PR:000014896) 2330: Sine oculis homeobox 1 protein expression, increased
1112 increased cell proliferation (GO:0008283) homeobox protein SIX1 (PR:000014896) 1066: Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium
1114 increased peptide biosynthetic process (GO:0043043) 2371: Increased cortisol
1116 increased estrogen receptor activity (GO:0030284) estrogen receptor alpha complex (PR:000027727) 1065: Activation, estrogen receptor alpha
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1121 increased hormone secretion (GO:0046879) gonadotropin releasing neuron (CL:0011111) 2137: Increase, Gonadotropins concentration in plasma
1122 increased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987) 1047: Increased, secretion of GnRH from hypothalamus
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1137 increased regulation of steroid hormone biosynthetic process (GO:0090030) 17beta-estradiol (CHEBI:16469) 2402: Increased, estradiol (E2) production in ovaries
1138 increased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 1985: Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)
1139 increased increased circulating estradiol level (MP:0005182) 17beta-estradiol (CHEBI:16469) 2294: Plasma estradiol, increased
1140 increased increased uterus weight (MP:0004904) body of uterus (UBERON:0009853) 2413: Increased, uterine weight
1141 increased abnormal reproductive system development (MP:0003936) reproductive organ (UBERON:0003133) 2415: Precocious puberty
1142 increased female gonad development (GO:0008585) female organism (UBERON:0003100) None
1143 increased female gonad development (GO:0008585) None
1144 increased female sex determination (GO:0030237) population of organisms (PCO:0000001) 2418: Increased, phenotypic female-biased sex ratio
1145 increased female gonad development (GO:0008585) immature gonad (UBERON:2005272) 2417: Increased, differentiation to ovaries
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation
1 increased cell proliferation (GO:0008283)
2 increased hyperplasia (MESH:D006965)