Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
235 decreased sodium:iodide symporter activity (GO:0008507) sodium/iodide cotransporter (PR:000015171) 424: Inhibition, Na+/I- symporter (NIS)
438 decreased renal absorption (GO:0070293) sodium(1+) (CHEBI:29101) 821: Decreased, Sodium reabsorption
636 decreased transport (GO:0006810) sodium(1+) (CHEBI:29101) 1176: Decreased, sodium conductance 2
1013 decreased sodium:potassium-exchanging ATPase activity (GO:0005391) sodium:potassium-exchanging ATPase complex (GO:0005890) 1562: Decreased Na/K ATPase activity
336 decreased neurotransmitter reuptake (GO:0098810) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
338 decreased serotonin secretion (GO:0001820) sodium-dependent serotonin transporter (PR:000015189) 626: Increased, serotonin (5-HT)
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
325 decreased sodium channel inhibitor activity (GO:0019871) sodium channel protein type 1 subunit alpha (PR:000002095)
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
988 decreased import into cell (GO:0098657) sodium atom (CHEBI:26708) None
631 increased reflex (GO:0060004) sneezing (MESH:D012912) 1434: Irritation of nasal mucosa inducing sneeze reflex
881 decreased receptor antagonist activity (GO:0048019) smoothened homolog (human) (PR:Q99835) None
882 decreased smoothened (PR:000015288) None
883 decreased regulation of receptor activity (GO:0010469) smoothened (PR:000015288) 2027: Antagonism, Smoothened receptor
897 decreased protein localization to cilium (GO:0061512) smoothened (PR:000015288) 2044: Decrease, Smoothend relocation and activation
542 increased hypertrophy (MESH:D006984) smooth muscle tissue (UBERON:0001135) 1043: Hypertrophy/hyperplasia, smooth muscle
541 increased cell proliferation (GO:0008283) smooth muscle cell (CL:0000192) 1042: Proliferation/Clonal Expansion, smooth muscle
926 functional change smooth muscle cell (CL:0000192) 2096: Occurrence, (Micro)vascular dysfunction
860 increased DNA damage response, detection of DNA damage (GO:0042769) site of DNA damage (GO:0090734)
787 decreased type I interferon signaling pathway (GO:0060337) signalling molecule (CHEBI:62488) None
748 decreased protein dephosphorylation (GO:0006470) signal transducer and transcription activator STAT (PR:000001933) 1716: Blockade of STAT5 phosphorylation
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
640 increased estrogen receptor binding (GO:0030331) serotransferrin (PR:000016261) 1188: Increased, ER binding to T.F. to DNA (non-classical pathway)
1078 increased serotonin receptor signaling pathway (GO:0007210) Serotonin receptor (FMA:67372) None