Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown
435 decreased signaling (GO:0023052) alpha-2A adrenergic receptor (PR:000001186) 849: Inhibition, Antgonism of NE receptor
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
338 decreased serotonin secretion (GO:0001820) sodium-dependent serotonin transporter (PR:000015189) 626: Increased, serotonin (5-HT)
1078 increased serotonin receptor signaling pathway (GO:0007210) Serotonin receptor (FMA:67372) None
1080 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 1A (PR:000001161) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1081 increased serotonin receptor signaling pathway (GO:0007210) 5-hydroxytryptamine receptor 2C (PR:000001168) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
1075 increased serotonin receptor activity (GO:0099589) Surface of brain (FMA:86594) 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
525 decreased sensory perception of sound (GO:0007605) 1008: Reduced, Hearing
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
56 decreased secretion (GO:0046903) brain-derived neurotrophic factor (PR:000004716) 381: Reduced levels of BDNF
238 decreased secretion (GO:0046903) very-low-density lipoprotein (CHEBI:39027) 450: Decrease, Very low-density lipoprotein export capacity
532 increased secretion (GO:0046903) eukaryotic protein (PR:000036194) 1032: Increased, secretion of local growth factors
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
896 decreased second-messenger-mediated signaling (GO:0019932) None
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
578 abnormal role (MESH:D012380) 1108: Abnormal, Role change within caste
616 decreased rhythmic excitation (GO:0043179) vagus nerve (UBERON:0001759) 1220: Trigeminal nerve activation
343 decreased rhythmic excitation (GO:0043179) histaminergic neuron (CL:0011110) 633: Decrease, histaminergic neuron excitation