Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 176 to 200 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
3 increased hepatocellular carcinoma (MESH:D006528) 334: Promotion, Hepatocelluar carcinoma
10 increased loss of dopaminergic neurons (MP:0003244) 890: Degeneration of dopaminergic neurons of the nigrostriatal pathway
12 increased ecdysone receptor-mediated signaling pathway (GO:0035076) ecdysone receptor holocomplex (GO:0008230) 103: Increase, Ecdysone receptor hyperactivation
14 increased chitin biosynthetic process (GO:0006031) chitin (CHEBI:17029) 990: Increase, Incomplete ecdysis
15 increased muscle contraction (GO:0006936)
16 increased mortality (MESH:D009026)
17 increased gene expression (GO:0010467) Eip75B protein, Drosophila (MESH:C061375) 1264: Increase, Nuclear receptor E75b gene expression
18 increased gene expression (GO:0010467) nuclear hormone receptor FTZ-F1 (fruit fly) (PR:P33244) 1265: Decrease, Fushi tarazu factor-1 gene expression
22 increased receptor antagonist activity (GO:0048019) peroxisome proliferator-activated receptor alpha (PR:000013056) 998: Binding of antagonist, PPAR alpha
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
24 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 1 (PR:000011047) 1000: stabilization, PPAR alpha co-repressor
30 increased protein catabolic process (GO:0030163) muscle protein (MESH:D009124) 863: Increased, Catabolism of Muscle Protein
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
38 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 715: Activation, Constitutive androstane receptor
39 increased glucuronosyltransferase activity (GO:0015020) beta-1,3-glucuronyltransferase (PR:000001325) 295: Induction, Upregulation of glucuronyltransferase activity
40 increased excretion (GO:0007588) Tetrahydroaldosterone-3-glucuronide (CHEBI:88728) 401: Increase, Biliary excretion TH glucuronide
45 increased cochlear degeneration (MP:0000032) 319: Loss, Cochlear function
46 increased GABA receptor binding (GO:0050811) gamma-aminobutyric acid receptor subunit alpha-1 (PR:000007766) 667: Binding at picrotoxin site, iGABAR chloride channel
47 increased GABA receptor binding (GO:0050811) gamma-aminobutyric acid receptor subunit alpha-5 (PR:000007770) 667: Binding at picrotoxin site, iGABAR chloride channel
48 increased GABA receptor binding (GO:0050811) gamma-aminobutyric acid receptor subunit alpha-6 (PR:000007771) 667: Binding at picrotoxin site, iGABAR chloride channel
57 increased cell death (GO:0008219)
58 increased neurodegeneration (MP:0002229) 352: N/A, Neurodegeneration
65 increased glucocorticoid receptor activity (GO:0004883) glucocorticoid receptor (PR:000011406)
69 increased I-kappaB phosphorylation (GO:0007252) NF-kappa-B inhibitor (PR:000003292) 145: Induction, IKB inhibitory protein
70 increased suppression of host defenses (GO:0044414) immune system (UBERON:0002405) 403: Suppression, Immune system