Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 176 to 200 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
126 increased bile (UBERON:0001970) 214: Bile accumulation, Pathological condition
127 increased cytokine secretion (GO:0050663) Cytokine (FMA:84050) 87: Release, Cytokine
168 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor gamma (PR:000013058) 228: peroxisome proliferator activated receptor promoter demethylation
169 increased gene expression (GO:0010467) platelet glycoprotein 4 (PR:000001905) 54: Up Regulation, CD36
170 increased positive regulation of fatty acid transport (GO:2000193) fatty acid (CHEBI:35366) 115: Increase, Fatty acid influx
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation
173 increased fatty acid synthase activity (GO:0004312) fatty acid synthase (PR:000007348) 116: Activation, FAS
176 increased triglyceride (CHEBI:17855) 291: Accumulation, Triglyceride
178 occurrence fatty liver (MESH:D005234) 345: N/A, Liver Steatosis
179 increased membrane (GO:0016020) 46: Accumulation, Biological membranes
180 abnormal plasma membrane (GO:0005886) 169: Disruption, Membrane integrity
182 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor delta (PR:000013057) 232: Decreased, PPAR-beta activation
184 increased fatty acid (CHEBI:35366) 327: Accumulation, Fatty acid
185 decreased gene expression (GO:0010467) 3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774) 140: Decreased, HSD17B10 expression
188 increased collagen biosynthetic process (GO:0032964) collagen (CHEBI:3815) 68: Increase, Collagen accumulation
189 increased hepatic stellate cell activation (GO:0035733) hepatic stellate cell (CL:0000632) 265: Increase, Hepatic stellate cell activation
190 increased protein alkylation (GO:0008213) 244: Alkylation, Protein
191 increased macrophage activation (GO:0042116) Kupffer cell (CL:0000091) 134: Increase, Kupffer cell activation
193 increased transforming growth factor beta1 production (GO:0032905) TGF-beta 1 (PR:000000182) 276: Up Regulation, TGFbeta1 expression
194 increased covalent binding (MI:0195) xenobiotic (CHEBI:35703) 75: N/A, Covalent binding to protein, possibly lysine residue
195 increased chemokine activity (GO:0008009) Chemokine (FMA:241981) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
196 increased cytokine activity (GO:0005125) Cytokine (FMA:84050) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
197 increased Respiratory Hypersensitivity (MESH:D012130) 313: Increase, Allergic Respiratory Hypersensitivity Response
198 increased protein binding (GO:0005515) electrophilic reagant (CHEBI:59739) 396: Covalent Binding, Protein
199 increased keratinocyte activation (GO:0032980) 826: Activation, Keratinocytes