Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 176 to 200 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1059 decreased retinoic acid biosynthetic process (GO:0002138) retinal dehydrogenase 1 (PR:000003920) 1880: Decreased, ALDH1A (RALDH) enzyme activity
1060 decreased retinoic acid biosynthetic process (GO:0002138) all-trans-retinoic acid (CHEBI:15367) 1881: Decreased, all-trans retinoic acid (atRA) concentration
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure
308 functional change response to wounding (GO:0009611) Mitochondrial deoxyribonucleic acid (FMA:67199) 570: Accumulation, Damaged mitochondrial DNA
765 increased response to reactive oxygen species (GO:0000302) reactive oxygen species (CHEBI:26523)
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
197 increased Respiratory Hypersensitivity (MESH:D012130) 313: Increase, Allergic Respiratory Hypersensitivity Response
481 decreased respiratory function trait (VT:0002327) 1250: Decrease, Lung function
919 increased respiratory electron transport chain (GO:0022904) superoxide (CHEBI:18421) 2120: Superoxide generation, increased
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
611 increased reproductive process (GO:0022414) 1163: Increased, Reproductive Success
306 decreased reproductive behavior (GO:0019098) 565: Reduced, Brood care
141 abnormal reproductive behavior (GO:0019098) 363: Altered, Reproductive behaviour
350 decreased reproduction (GO:0000003)
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
438 decreased renal absorption (GO:0070293) sodium(1+) (CHEBI:29101) 821: Decreased, Sodium reabsorption
540 increased relaxation of smooth muscle (GO:0044557) 1040: relaxation, smooth muscle
1123 decreased regulation of vascular permeability (GO:0043114) None
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1137 increased regulation of steroid hormone biosynthetic process (GO:0090030) 17beta-estradiol (CHEBI:16469) 2402: Increased, estradiol (E2) production in ovaries
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
289 abnormal regulation of steroid biosynthetic process (GO:0050810) 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
766 occurrence regulation of response to reactive oxygen species (GO:1901031) reactive oxygen species (CHEBI:26523) 1634: Increase, Oxidative DNA damage
883 decreased regulation of receptor activity (GO:0010469) smoothened (PR:000015288) 2027: Antagonism, Smoothened receptor