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OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification
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This AOP page was last modified on 12/11/2016.
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Summary of the AOP
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Molecular Initiating Event
|Molecular Initiating Event||Support for Essentiality|
|Cyclooxygenase activity, Inhibition||Weak|
|Event||Support for Essentiality|
|Prostaglandin F2alpha concentration, plasma , Reduced||Moderate|
|Prostaglandin F2alpha synthesis, ovary , Reduced||Moderate|
|Spawning behavior, Reduced||Moderate|
|Ability to attract spawning mates, Reduced||Weak|
|Reproductive Success, Reduced|
|Population trajectory, Decrease|
Relationships Among Key Events and the Adverse Outcome
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Life Stage Applicability
|Adult, reproductively mature||Strong|
Overall Assessment of the AOP
Domain of Applicability
Life Stage Applicability,
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Weight of Evidence Summary
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.