Aop:104

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/104


AOP Title

Altered ion channel activity leading impaired heart function
Short name: chemical-induced arrthymias

Authors

Kevin Dreher, US EPA

Status

Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification Please follow the link to snapshots page to view and create Snapshots of this AOP.

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
ion channels, impaired

Key Events

Event Support for Essentiality
Action Potential, Altered
cardiac arrthymia, Increased

Adverse Outcome

Adverse Outcome
Mortality, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
ion channels, impaired Directly Leads to Action Potential, Altered
Action Potential, Altered Directly Leads to cardiac arrthymia, Increased
cardiac arrthymia, Increased Directly Leads to Mortality, Increased

Network View

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Life Stage Applicability

Life Stage Evidence Links
all life stages

Taxonomic Applicability

Name Scientific Name Evidence Links

Sex Applicability

Sex Evidence Links
Unspecific

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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Considerations for Potential Applications of the AOP (optional)

References