Aop:123

From AOP-Wiki
Jump to: navigation, search

Status

This is a legacy representation of this AOP. Please see the current version here:

https://training.aopwiki.org/aops/123


AOP Title

Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
Short name: Unknown MIE leading to reprodl

Authors

Dalma Martinovic-Weigelt

Status

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Please follow the link to snapshots page to view and create Snapshots of this AOP.

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

Click here to show/hide revision dates for related pages

Page Revision Date/Time

Abstract

Background (optional)

Summary of the AOP

Please follow link to widget page to edit this section.

If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.

Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Unknown, modulation

Key Events

Event Support for Essentiality
HIF-1 heterodimer, Increased Weak
HIF-1 alpha transcription, Increased
Aromatase (Cyp19a1) mRNA, Decreased
Plasma 17beta-estradiol concentrations, Reduction
17beta-estradiol synthesis by ovarian granulosa cells, Reduction
Vitellogenin synthesis in liver, Reduction
Plasma vitellogenin concentrations, Reduction
Vitellogenin accumulation into oocytes and oocyte growth/development, Reduction

Adverse Outcome

Adverse Outcome
Cumulative fecundity and spawning, Reduction
Population trajectory, Decrease

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Unknown, modulation Directly Leads to HIF-1 alpha transcription, Increased
HIF-1 alpha transcription, Increased Directly Leads to HIF-1 heterodimer, Increased Weak Weak
HIF-1 heterodimer, Increased Directly Leads to Aromatase (Cyp19a1) mRNA, Decreased Weak
Aromatase (Cyp19a1) mRNA, Decreased Directly Leads to 17beta-estradiol synthesis by ovarian granulosa cells, Reduction
17beta-estradiol synthesis by ovarian granulosa cells, Reduction Directly Leads to Plasma 17beta-estradiol concentrations, Reduction
Plasma 17beta-estradiol concentrations, Reduction Directly Leads to Vitellogenin synthesis in liver, Reduction
Vitellogenin synthesis in liver, Reduction Directly Leads to Plasma vitellogenin concentrations, Reduction
Plasma vitellogenin concentrations, Reduction Directly Leads to Vitellogenin accumulation into oocytes and oocyte growth/development, Reduction
Vitellogenin accumulation into oocytes and oocyte growth/development, Reduction Directly Leads to Cumulative fecundity and spawning, Reduction
Cumulative fecundity and spawning, Reduction Directly Leads to Population trajectory, Decrease

Network View

   Cytoscape Web will replace the contents of this div with your graph.

Click nodes or edges.

Life Stage Applicability

Life Stage Evidence Links
Adult, reproductively mature

Taxonomic Applicability

Name Scientific Name Evidence Links
Pimephales promelas Pimephales promelas NCBI

Sex Applicability

Sex Evidence Links
Female

Graphical Representation

Click to upload graphical representation

Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.

Weight of Evidence Summary

Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.

Quantitative Considerations

Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.

Considerations for Potential Applications of the AOP (optional)

References