Aop:139

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/139


AOP Title

Alkylation of DNA leading to cancer
Short name: DNA alkylation -> cancer

Authors

Carole Yauk

Environmental Health Centre Health Canada 50 Colombine Driveway Ottawa, ON Canada K1S 0K1

email: Carole.Yauk@canada.ca

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
DNA, Alkylation

Key Events

Event Support for Essentiality
Insufficient or incorrect DNA repair, N/A
Mutations, Increase

Adverse Outcome

Adverse Outcome
Cancer, Increase

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
DNA, Alkylation Directly Leads to Insufficient or incorrect DNA repair, N/A Strong Moderate
Insufficient or incorrect DNA repair, N/A Indirectly Leads to Mutations, Increase Strong Moderate
Mutations, Increase Indirectly Leads to Cancer, Increase Moderate Weak
DNA, Alkylation Indirectly Leads to Mutations, Increase Strong Moderate
DNA, Alkylation Indirectly Leads to Cancer, Increase Moderate Weak

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Life Stage Applicability

Life Stage Evidence Links
all life stages Moderate

Taxonomic Applicability

Name Scientific Name Evidence Links
Homo sapiens Homo sapiens NCBI
Mus musculus Mus musculus NCBI

Sex Applicability

Sex Evidence Links
Mixed Moderate

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

References