Aop:14

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://training.aopwiki.org/aops/14

AOP Title

Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
Short name: Glucocorticoid Receptor, Activation

Authors

Carlie A. LaLone, University of Minnesota, Water Resources Center, lalone.carlie@epa.gov

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP was last modified on 12/5/2016.

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Abstract

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Glucocorticoid Receptor, Activation

Key Events

Event Support for Essentiality
Nuclear factor kappa B (NF-kB), Inhibition
Inflammatory cytokines, Suppression
Lymphocytes, Decreased
IKB inhibitory protein, Induction
Immune system, Suppression

Adverse Outcome

Adverse Outcome
Disease susceptibility, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Glucocorticoid Receptor, Activation Directly Leads to IKB inhibitory protein, Induction
IKB inhibitory protein, Induction Directly Leads to Nuclear factor kappa B (NF-kB), Inhibition
Nuclear factor kappa B (NF-kB), Inhibition Directly Leads to Inflammatory cytokines, Suppression
Inflammatory cytokines, Suppression Directly Leads to Lymphocytes, Decreased
Lymphocytes, Decreased Directly Leads to Immune system, Suppression

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Overall Assessment of the AOP

Weight of Evidence Summary

Summary Table
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Quantitative Considerations

Summary Table
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Applicability of the AOP

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Considerations for Potential Applications of the AOP (optional)

References