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Carlie A. LaLone, University of Minnesota, Water Resources Center, firstname.lastname@example.org
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This AOP was last modified on 12/5/2016.
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Summary of the AOP
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Molecular Initiating Event
|Molecular Initiating Event||Support for Essentiality|
|Glucocorticoid Receptor, Activation|
|Event||Support for Essentiality|
|Nuclear factor kappa B (NF-kB), Inhibition|
|Inflammatory cytokines, Suppression|
|IKB inhibitory protein, Induction|
|Immune system, Suppression|
|Disease susceptibility, Increased|
Relationships Among Key Events and the Adverse Outcome
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Life Stage Applicability
Overall Assessment of the AOP
Weight of Evidence Summary
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.
Applicability of the AOP
Life Stage Applicability,
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.