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This is a legacy representation of this AOP. Please see the current version here:

AOP Title

Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation
Short name: TPOi anterior swim bladder


Dries Knapen [1], [dries.knapen (at)]

Lucia Vergauwen [1], [lucia.vergauwen(at)]

Evelyn Stinckens [1], [evelyn.stinckens(at)]

Dan Villeneuve [2], [villeneuve.dan*(at)]

[1] Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
[2]United States Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA.


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This AOP page was last modified on 12/11/2016.

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OECD EAGMST AOP Development Programme Project 1.35: The adverse outcome pathway on thyroperoxidase and/or deiodinase inhibition leading to impaired swim bladder inflation in fish during early life stages.


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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Thyroperoxidase, Inhibition

Key Events

Event Support for Essentiality
Thyroid hormone synthesis, Decreased
Thyroxin (T4) in serum, Decreased
Anterior swim bladder inflation, Reduced
Hearing, Reduced
Swimming performance, Reduced
Young of year survival, Reduced

Adverse Outcome

Adverse Outcome
Population trajectory, Decrease

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Thyroxin (T4) in serum, Decreased Directly Leads to Anterior swim bladder inflation, Reduced
Anterior swim bladder inflation, Reduced Directly Leads to Hearing, Reduced
Hearing, Reduced Directly Leads to Young of year survival, Reduced
Young of year survival, Reduced Directly Leads to Population trajectory, Decrease
Anterior swim bladder inflation, Reduced Directly Leads to Swimming performance, Reduced
Swimming performance, Reduced Directly Leads to Young of year survival, Reduced

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

Sex Applicability

Sex Evidence Links

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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