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This is a legacy representation of this AOP. Please see the current version here:

AOP Title

Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
Short name: iGABAR activation leading to mortality


You Song1, Knut Erik Tollefsen1,2

1Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway

2Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 Ås, Norway



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This AOP page was last modified on 12/11/2016.

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
ionotropic GABA Receptor chloride channel, Activation Strong

Key Events

Event Support for Essentiality
Inhibitory postsynaptic potential, Increased
Somatic muscle paralysis, Induction
Chloride conductance, Increased Strong
Neuronal synaptic inhibition, Increased
Feeding, Inhibition

Adverse Outcome

Adverse Outcome
Mortality, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Somatic muscle paralysis, Induction Directly Leads to Mortality, Increased
ionotropic GABA Receptor chloride channel, Activation Directly Leads to Chloride conductance, Increased
Chloride conductance, Increased Directly Leads to Neuronal synaptic inhibition, Increased
Neuronal synaptic inhibition, Increased Directly Leads to Inhibitory postsynaptic potential, Increased
Inhibitory postsynaptic potential, Increased Directly Leads to Somatic muscle paralysis, Induction
Somatic muscle paralysis, Induction Directly Leads to Feeding, Inhibition
Feeding, Inhibition Directly Leads to Mortality, Increased

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Daphnia magna Daphnia magna NCBI

Sex Applicability

Sex Evidence Links

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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