Aop:161

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/161


AOP Title

Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
Short name: GluCl activation leading to mortality

Authors

You Song1, Knut Erik Tollefsen1,2

1Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway

2Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 Ås, Norway

Contact: knut.erik.tollefsen@niva.no

Status

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Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

Background (optional)

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Glutamate-gated chloride channels, Activation

Key Events

Event Support for Essentiality
Neuronal synaptic inhibition, Increased
Inhibitory postsynaptic potential, Increased
Feeding, Inhibition
Chloride conductance, Increased
pharyngeal muscle paralysis, Induction

Adverse Outcome

Adverse Outcome
Mortality, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Neuronal synaptic inhibition, Increased Directly Leads to Inhibitory postsynaptic potential, Increased
Feeding, Inhibition Directly Leads to Mortality, Increased
Glutamate-gated chloride channels, Activation Directly Leads to Chloride conductance, Increased
Chloride conductance, Increased Directly Leads to Neuronal synaptic inhibition, Increased
Inhibitory postsynaptic potential, Increased Directly Leads to pharyngeal muscle paralysis, Induction
pharyngeal muscle paralysis, Induction Directly Leads to Feeding, Inhibition

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
nematode Caenorhabditis elegans NCBI
Daphnia magna Daphnia magna NCBI

Sex Applicability

Sex Evidence Links

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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Considerations for Potential Applications of the AOP (optional)

References