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This is a legacy representation of this AOP. Please see the current version here:

AOP Title

unknown MIE leading to renal failure and mortality
Short name: unknown MIE renal failure


Kellie Fay


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This AOP page was last modified on 12/11/2016.

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
MIE, Unknown

Key Events

Event Support for Essentiality
Reactive oxygen species, Increased Weak
Oxidative Stress, Increased
renal proximal tubular necrosis, Occurrence
blood potassium concentration, Increased
cardiac arrhythmia, Occurrence

Adverse Outcome

Adverse Outcome
Mortality, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
MIE, Unknown Directly Leads to Reactive oxygen species, Increased
Reactive oxygen species, Increased Directly Leads to Oxidative Stress, Increased
Oxidative Stress, Increased Indirectly Leads to renal proximal tubular necrosis, Occurrence
renal proximal tubular necrosis, Occurrence Directly Leads to blood potassium concentration, Increased
blood potassium concentration, Increased Directly Leads to cardiac arrhythmia, Occurrence
cardiac arrhythmia, Occurrence Directly Leads to Mortality, Increased

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

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Sex Applicability

Sex Evidence Links

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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