Aop:192

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/192


AOP Title

Pendrin inhibition leading to altered amphibian metamorphosis
Short name: Pendrin inhib alters metamorphosis

Authors

Jonathan T. Haselman, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <haselman.jon@epa.gov>

Sigmund J. Degitz, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <degitz.sigmund@epa.gov>

Michael W. Hornung, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <hornung.michael@epa.gov>

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

Background (optional)

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Pendrin, Inhibition Weak

Key Events

Event Support for Essentiality
Thyroid hormone synthesis, Decreased Strong
Thyroxine (T4) in serum, Decreased Strong
Thyroxine (T4) in tissues, Decreased Moderate
Triiodothyronine (T3) in tissues, Decreased Moderate

Adverse Outcome

Adverse Outcome
Amphibian metamorphosis, Altered

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Pendrin, Inhibition Directly Leads to Thyroid hormone synthesis, Decreased Weak Weak

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Life Stage Applicability

Life Stage Evidence Links
development Strong

Taxonomic Applicability

Name Scientific Name Evidence Links
African clawed frog Xenopus laevis Weak NCBI

Sex Applicability

Sex Evidence Links
Unspecific Strong

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

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Quantitative Considerations

Summary Table
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Considerations for Potential Applications of the AOP (optional)

References