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AOP Title

5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
Short name: 5-HTT leading to population increase


Kellie Fay


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This AOP page was last modified on 12/11/2016.

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Increased serotonergic activity resulting from the inhibition of the 5-hydroxytryptamin transporter (5-HTT; SERT; serotonin reuptake transporter) may result in increased population levels of certain mollusks, specifically invasive mussels. Gamete maturation and release are under serotonergic control and several mussel species have been reported to release viable gametes (both sperm and oocytes)upon exposure to serotonin or 5-HTT inhibitors, which increase serotonergic signalling. Given the critically low population levels of many Unionid species and the difficulty in managing several invasive (Dreissenid; e.g., zebra mussel) species, increased reproductive success may result in adverse outcomes at an ecosystem level.

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
5-hydroxytryptamine transporter (5-HTT; SERT), Inhibition Strong

Key Events

Event Support for Essentiality
serotonin (5-HT) , Increased
mantel display, Increased
gamete maturation, Increased
cilia movement, Increased
Spawning , premature
Reproductive Success, Increased

Adverse Outcome

Adverse Outcome
Population, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
serotonin (5-HT) , Increased Directly Leads to mantel display, Increased
serotonin (5-HT) , Increased Directly Leads to cilia movement, Increased
cilia movement, Increased Directly Leads to Spawning , premature
Spawning , premature Directly Leads to Population, Increased
serotonin (5-HT) , Increased Indirectly Leads to gamete maturation, Increased
gamete maturation, Increased Directly Leads to Reproductive Success, Increased
mantel display, Increased Indirectly Leads to Reproductive Success, Increased
Reproductive Success, Increased Directly Leads to Population, Increased

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Argopecten irradians Argopecten irradians Weak NCBI
Mercenaria mercenaria Mercenaria mercenaria Weak NCBI
Arctica islandica Arctica islandica Weak NCBI
Spisula solidissima Spisula solidissima Weak NCBI
Anodonta cygnea Anodonta cygnea Weak NCBI
Dreissena polymorpha Dreissena polymorpha Weak NCBI

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

This aop should be considered highly putative. SSRI effects in mussels have been fairly well documented as a method to increase reproduction in aquaculture settings, but the implications on natural population and potential ecosystem effects are unknown.

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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