Aop:53

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/53


AOP Title

ER agonism leading to reduced survival due to renal failure
Short name: ER agonism : reduced survival

Authors

Status

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Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Estrogen receptor, Agonism

Key Events

Event Support for Essentiality
Vitellogenin synthesis, Increased
Plasma vitellogenin concentrations, Increase
renal vitellogenin deposition, Increased
glomerular rupture and renal hemorrhaging, Increased
nephropathy, Increased

Adverse Outcome

Adverse Outcome

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding

Network View

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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Considerations for Potential Applications of the AOP (optional)

References