Aop:66

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/66


AOP Title

Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
Short name: Decreased Fetal Testosterone

Authors

Gary Klinefelter and Susan Laws

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

Background (optional)

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Increased corticosterone, Decreased testosterone by the fetal Leydig cells Strong
Activation by other glucocorticoid receptor agonists, Decreased testosterone by the fetal Leydig cells Strong

Key Events

Event Support for Essentiality
Increased COUP-TFII in fetal Leydig cells, Decreased testosterone by the fetal Leydig cells Strong
Dysgenesis of fetal Leydig cells, Decreased testosterone by the fetal Leydig cells Strong
Decreased COUP-TFII stem Leydig cells, Decreased number and function of adult Leydig cells Strong

Adverse Outcome

Adverse Outcome
Decreased fertility , Decreased sperm quantity / quality in the adult

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding

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Life Stage Applicability

Life Stage Evidence Links
Foetal Strong
Adult, reproductively mature Moderate

Taxonomic Applicability

Name Scientific Name Evidence Links
Rattus norvegicus Rattus norvegicus Strong NCBI

Sex Applicability

Sex Evidence Links
Male Strong

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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Considerations for Potential Applications of the AOP (optional)

References