From AOP-Wiki
Jump to: navigation, search


This is a legacy representation of this AOP. Please see the current version here:

AOP Title

Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
Short name: nAChR activation - colony loss


Carlie A. LaLone, U.S. Environmental Protection Agency (


Please follow the link to snapshots page to view and create Snapshots of this AOP.

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

Click here to show/hide revision dates for related pages

Page Revision Date/Time


Background (optional)

Summary of the AOP

Please follow link to widget page to edit this section.

If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.

Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Nicotinic acetylcholine receptor, Activation Strong

Key Events

Event Support for Essentiality
Mitochondrial dysfunction, N/A Strong
Ca2+-calmodulin activated signal transduction, Altered
Learning and memory, Impairment Strong
Foraging activity and behavior, Abnormal Strong
Colony, Weakened Strong

Adverse Outcome

Adverse Outcome
Colony, Death/Failure

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Nicotinic acetylcholine receptor, Activation Directly Leads to Mitochondrial dysfunction, N/A
Learning and memory, Impairment Directly Leads to Foraging activity and behavior, Abnormal
Foraging activity and behavior, Abnormal Directly Leads to Colony, Weakened
Colony, Weakened Directly Leads to Colony, Death/Failure
Nicotinic acetylcholine receptor, Activation Indirectly Leads to Learning and memory, Impairment
Mitochondrial dysfunction, N/A Directly Leads to Ca2+-calmodulin activated signal transduction, Altered
Ca2+-calmodulin activated signal transduction, Altered Directly Leads to Learning and memory, Impairment

Network View

   Cytoscape Web will replace the contents of this div with your graph.

Click nodes or edges.

Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Honey bee

Sex Applicability

Sex Evidence Links

Graphical Representation

Click to upload graphical representation

Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.

Weight of Evidence Summary

Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.

Quantitative Considerations

Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.

Considerations for Potential Applications of the AOP (optional)