Aop:80

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/80


AOP Title

Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
Short name: nAChR activation - colony loss

Authors

Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

Background (optional)

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Nicotinic acetylcholine receptor, Activation

Key Events

Event Support for Essentiality
Mitochondrial dysfunction, N/A
Damaged mitochondrial DNA, Accumulation
Aging, Accelerated
Mitochondrial DNA repair mechanisms, Overwhelmed

Adverse Outcome

Adverse Outcome
Number of worker bees, Decrease
Hive thermoregulation, impaired
Colony, Death/Failure

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Nicotinic acetylcholine receptor, Activation Directly Leads to Mitochondrial dysfunction, N/A
Mitochondrial dysfunction, N/A Directly Leads to Mitochondrial DNA repair mechanisms, Overwhelmed
Mitochondrial DNA repair mechanisms, Overwhelmed Directly Leads to Damaged mitochondrial DNA, Accumulation
Damaged mitochondrial DNA, Accumulation Directly Leads to Aging, Accelerated
Aging, Accelerated Directly Leads to Number of worker bees, Decrease
Number of worker bees, Decrease Directly Leads to Hive thermoregulation, impaired
Hive thermoregulation, impaired Directly Leads to Colony, Death/Failure

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Honey bee

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

References