Aop:86

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/86


AOP Title

Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
Short name: Glucose oxidase - Colony loss

Authors

Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality

Key Events

Event Support for Essentiality
Glucose oxidase enzyme activity, Decreased
Hydrogen peroxide production, Decreased
Antiseptic incorporated in food, Reduced
Roll change within caste, Abnormal
Food storage, Reduced

Adverse Outcome

Adverse Outcome
Larval development, impaired
Colony, Death/Failure

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Glucose oxidase enzyme activity, Decreased Directly Leads to Hydrogen peroxide production, Decreased
Hydrogen peroxide production, Decreased Directly Leads to Antiseptic incorporated in food, Reduced
Antiseptic incorporated in food, Reduced Directly Leads to Roll change within caste, Abnormal
Roll change within caste, Abnormal Directly Leads to Food storage, Reduced
Food storage, Reduced Directly Leads to Larval development, impaired
Larval development, impaired Directly Leads to Colony, Death/Failure

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Honey bee

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

References