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This is a legacy representation of this AOP. Please see the current version here:

AOP Title

Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure
Short name: nAChR activation - colony loss


Carlie A. LaLone, U.S. Environmental Protection Agency


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OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Nicotinic acetylcholine receptor, Activation

Key Events

Event Support for Essentiality
Learning and memory, Impairment
Roll change within caste, Abnormal
Brood care, Reduced
Nicotinic acetylcholine receptor, Desensitization
Neuronal network function in developing brain, Decreased

Adverse Outcome

Adverse Outcome
Larval development, impaired
Colony, Death/Failure

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Nicotinic acetylcholine receptor, Activation Directly Leads to Nicotinic acetylcholine receptor, Desensitization
Nicotinic acetylcholine receptor, Desensitization Directly Leads to Neuronal network function in developing brain, Decreased
Neuronal network function in developing brain, Decreased Directly Leads to Learning and memory, Impairment
Learning and memory, Impairment Directly Leads to Roll change within caste, Abnormal
Roll change within caste, Abnormal Directly Leads to Brood care, Reduced
Brood care, Reduced Directly Leads to Larval development, impaired
Larval development, impaired Directly Leads to Colony, Death/Failure

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Honey bee

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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