Aop:93

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Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/93


AOP Title

sodium channel inhibition leading to increased predation
Short name: sodium channel inhibition

Authors

Kellie Fay

Status

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OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
sodium channel, Inhibition Strong

Key Events

Event Support for Essentiality
Sodium conductance, Decreased Strong
swimming speed, Reduced Moderate

Adverse Outcome

Adverse Outcome
predation, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
sodium channel, Inhibition Directly Leads to Sodium conductance, Decreased Strong
Sodium conductance, Decreased Indirectly Leads to swimming speed, Reduced Moderate
swimming speed, Reduced Indirectly Leads to predation, Increased Moderate

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

Domain of Applicability

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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

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Quantitative Considerations

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References