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This is a legacy representation of this AOP. Please see the current version here:

AOP Title

5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
Short name: 5-HTT block to incr. predation


Bryan Brooks, Baylor University, USA

Kellie Fay, US EPA

Ksenia Groh, EAWAG, Switzerland


OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification

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This AOP page was last modified on 12/11/2016.

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Background (optional)

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
5-hydroxytryptamine transporter (5-HTT; SERT), Inhibition

Key Events

Event Support for Essentiality
serotonin (5-HT) , Increased
anxiety, Decreased
sheltering, Decreased

Adverse Outcome

Adverse Outcome
predation, Increased

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
5-hydroxytryptamine transporter (5-HTT; SERT), Inhibition Directly Leads to serotonin (5-HT) , Increased
serotonin (5-HT) , Increased Indirectly Leads to anxiety, Decreased
anxiety, Decreased Indirectly Leads to sheltering, Decreased
sheltering, Decreased Indirectly Leads to predation, Increased

Network View

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links
Pimephales promelas Pimephales promelas NCBI
Echinogammarus marinus Gammarus marinus NCBI

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

This putative AOP is based on a few studies in fish and mollusks and should be considered preliminary only.

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
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Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
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Weight of Evidence Summary

Summary Table
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Quantitative Considerations

Summary Table
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Considerations for Potential Applications of the AOP (optional)