Chem Init:15

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Chemical Initiator Title

Diclofenac sodium

Chemical Initiator Overview

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Molecular Initiating Events

The following are AOPs referencing this Chemical Initiator directly through Molecular Initiating Events:

AOP Name Molecular Initiating Event
Cyclooxygenase inhibition leading reproductive failure Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Cyclooxygenase inhibition leading to reproductive dysfunction Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase i /metaphase i transition #Cyclooxygenase activity, Inhibition
P-amino hippuric acid channel (pah) inhibition leading to renal failure and mortality #p-amino hippuric acid channel, Inhibition

Chemicals/Metabolites

The following are chemicals that operate within this chemical initiator:

Name Links Synonym Cas Smiles
Benzeneacetic acid, 2[(2,6-dichlorophenyl)amino]-, monosodium A Diclofenac sodium 15307-79-6 [O-]C(CC2=C(C=CC=C2)NC(C(Cl)=CC=C1)=C1Cl)=O.[Na+]

Chemical/Category Description

Characterization of Exposure

References