Chem Init:21

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Chemical Initiator Title

Domoic acid

Chemical Initiator Overview

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Molecular Initiating Events

The following are AOPs referencing this Chemical Initiator directly through Molecular Initiating Events:

  1. NMDARs, Binding of agonist
AOP Name Molecular Initiating Event
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. #Ionotropic glutamate receptors, Binding of agonist

Chemicals/Metabolites

The following are chemicals that operate within this chemical initiator:

Name Links Synonym Cas Smiles
Domoic Acid A Domoic Acid 14277-97-5

Chemical/Category Description

Characterization of Exposure

References