Chem Init:37

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Chemical Initiator Title

Methimazole

Chemical Initiator Overview

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Molecular Initiating Events

The following are AOPs referencing this Chemical Initiator directly through Molecular Initiating Events:

AOP Name Molecular Initiating Event
Inhibition of thyroperoxidase and subsequent adverse neurodevelopmental outcomes in mammals Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Thyroperoxidase inhibition leading to altered amphibian metamorphosis #Thyroperoxidase, Inhibition

Chemicals/Metabolites

The following are chemicals that operate within this chemical initiator:

Name Links Synonym Cas Smiles
Methimazole A Methimazole 60-56-0 N/1C(N(C=C1)C)=S

Chemical/Category Description

Characterization of Exposure

References