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Event Title

FA Influx, Increase
Short name: FA Influx, Increase

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
LXR activation leading to hepatic steatosis KE

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

Fat influx to the liver is usually increased under condition like obesity. Free fatty acids (FFA) increase in blood leads to an increase of FFA uptake in the liver. Especially the long chain fatty acids (LCFAs) are translocated across the plasma membrane, reassembled to triglycerides and stored in lipid droplets causing hepatic steatosis [1].

As mentioned above CD36 has consistently been shown to be expressed at the plasma membrane and to enhance LCFA uptake upon over-expression [2], [3].

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability


  1. Amacher 2011
  2. Baranowski 2008
  3. Su & Abumrad 2009