From AOP-Wiki
Jump to: navigation, search

Event Title

FAS, Activation
Short name: FAS, Activation

Key Event Overview

Please follow link to widget page to edit this section.

If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.

AOPs Including This Key Event

AOP Name Event Type Essentiality
LXR activation leading to hepatic steatosis KE

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

LXR agonist treatment has been shown to induce the genes encoding fatty acid synthase (FAS) in SREBP-1c-deficient mice [1], [2], [3].

This finding shows that in parallel with the increase of FAS expression from the SREBP-1c [2], [3], [4] and the ChREBP the enzyme is also directly induced from the LXR.

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability


  1. Oisterveer et al. 2010
  2. 2.0 2.1 Liang et al. 2002
  3. 3.0 3.1 Schultz et al. 2000
  4. Horton et al. 2002