Event:164

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Event Title

Liver “Dysfunctional” Changes by CGA 330050, Induction
Short name: Liver “Dysfunctional” Changes by CGA 330050, Induction

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors KE

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

References