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Event Title

Mitochondrial fatty acid beta-oxidation, Decreased
Short name: Mitochondrial fatty acid beta-oxidation, Decreased

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis KE
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis KE Strong

Taxonomic Applicability

Name Scientific Name Evidence Links
Homo sapiens Homo sapiens Strong NCBI

Level of Biological Organization

Biological Organization

How this Key Event works

Fatty acid oxidation in liver tissue is controlled by PPARalpha signaling networks (Evans et al 2004). The PPARalpha signaling network controls expression of the genes within metabolic pathways that catalyze fatty acid oxidation reactions (Desvergne and Wahli 1999).

How it is Measured or Detected

A variety of approaches establishing the effects of PPARalpha signaling on fatty acid oxidation are reviewed in Evans et al (2004).

Evidence Supporting Taxonomic Applicability

See review for Human PPARalpha signaling in (Evans et al 2004).


Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20(5): 649-688.

Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med 2004, 10(4):355-361.