Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis||KE|
|NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis||KE||Strong|
|Homo sapiens||Homo sapiens||Strong||NCBI|
Level of Biological Organization
How this Key Event works
Fatty acid oxidation in liver tissue is controlled by PPARalpha signaling networks (Evans et al 2004). The PPARalpha signaling network controls expression of the genes within metabolic pathways that catalyze fatty acid oxidation reactions (Desvergne and Wahli 1999).
How it is Measured or Detected
A variety of approaches establishing the effects of PPARalpha signaling on fatty acid oxidation are reviewed in Evans et al (2004).
Evidence Supporting Taxonomic Applicability
See review for Human PPARalpha signaling in (Evans et al 2004).
Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20(5): 649-688.
Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med 2004, 10(4):355-361.