Key Event Overview
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|LXR activation leading to hepatic steatosis||KE|
Level of Biological Organization
How this Key Event works
In addition to the FAS gene induction LXR activation leads to the direct induction of the stearoyl-CoA desaturase 1 (SCD1) in SREBP-1c-deficient mice , , . The role of SCD-1 could be crucial for the lipogenic activity of LXRs as there are data supporting that SCD-1 deficient mice are completely protected against hypertriglyceridemia and TG accumulation in liver is decreased after treatment with T0901317 .
How it is Measured or Detected
Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?
Evidence Supporting Taxonomic Applicability
- Oisterveer et al. 2010
- Liang et al. 2002
- Schultz et al. 2000
- Chu et al. 2006