Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|Binding to SH/selen-proteins can trigger neuroinflammation leading to neurodegeneration||MIE||Strong|
The following are chemical initiators that operate directly through this Event:
Level of Biological Organization
How this Key Event works
How it is Measured or Detected
Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?
Evidence Supporting Taxonomic Applicability
Farina M, Avila DS, da Rocha JB, Aschner M (2013) Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int 62: 575-594