Event:309

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Event Title

Vitellogenin accumulation into oocytes and oocyte growth/development, Reduction
Short name: Vitellogenin accumulation into oocytes and oocyte growth/development, Reduction

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Aromatase inhibition leading to reproductive dysfunction KE Weak
Androgen receptor agonism leading to reproductive dysfunction KE Weak
Estrogen receptor antagonism leading to reproductive dysfunction KE Weak
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation KE Moderate
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription KE

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

Vitellogenin from the blood is selectively taken up by competent oocytes via receptor-mediated endocytosis. Although vitellogenin receptors mediate the uptake, opening of intercellular channels through the follicular layers to the oocyte surface as the oocyte reaches a “critical” size is thought to be a key trigger in allowing vitellogenin uptake (Tyler and Sumpter 1996). Once critical size is achieved, concentrations in the plasma and temperature are thought to impose the primary limits on uptake (Tyler and Sumpter 1996). Uptake of vitellogenin into oocytes causes considerable oocyte growth during vitellogenesis, accounting for up to 95% of the final egg size in many fish (Tyler and Sumpter 1996). Given the central role of vitellogenesis in oocyte maturation, vitellogenin accumulation is a prominent feature used in histological staging of oocytes (e.g., (Leino et al. 2005; Wolf et al. 2004).

How it is Measured or Detected

Relative vitellogenin accumulation can be evaluated qualitatively using routine histological approaches (Leino et al. 2005; Wolf et al. 2004). Oocyte size can be evaluated qualitatively or quantitatively using routine histological and light microscopy and/or imaging approaches.

Evidence Supporting Taxonomic Applicability

Oviparous vertebrates and invertebrates. Although hormonal regulation of vitellogenin synthesis and mechanisms of vitellogenin transport from the site of synthesis to the ovary vary between vertebrates and invertebrates (Wahli 1988), in both vertebrates and invertebrates, vitellogenin is incorporated into oocytes and cleaved to form yolk proteins.

References

  • Tyler C, Sumpter J. 1996. Oocyte growth and development in teleosts. Reviews in Fish Biology and Fisheries 6: 287-318.
  • Leino R, Jensen K, Ankley G. 2005. Gonadal histology and characteristic histopathology associated with endocrine disruption in the adult fathead minnow. Environmental Toxicology and Pharmacology 19: 85-98.
  • Wolf JC, Dietrich DR, Friederich U, Caunter J, Brown AR. 2004. Qualitative and quantitative histomorphologic assessment of fathead minnow Pimephales promelas gonads as an endpoint for evaluating endocrine-active compounds: a pilot methodology study. Toxicol Pathol 32(5): 600-612.