Event:360

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Event Title

Population trajectory, Decrease
Short name: Population trajectory, Decrease

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Androgen receptor agonism leading to reproductive dysfunction AO
Aromatase inhibition leading to reproductive dysfunction AO
Estrogen receptor agonism leading to reproductive dysfunction AO
Estrogen receptor antagonism leading to reproductive dysfunction AO
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior AO
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation AO
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription AO
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation AO [[Aop:155#Essentiality of the Key Events|]]
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation AO [[Aop:156#Essentiality of the Key Events|]]
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation AO [[Aop:157#Essentiality of the Key Events|]]
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation AO [[Aop:158#Essentiality of the Key Events|]]
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation AO [[Aop:159#Essentiality of the Key Events|]]

Taxonomic Applicability

Name Scientific Name Evidence Links
all species

Affected Organs

Synonym Scientific Name Evidence Links

Level of Biological Organization

Biological Organization
Individual

How this Key Event works

Maintenance of sustainable fish and wildlife populations (i.e., adequate to ensure long-term delivery of valued ecosystem services) is an accepted regulatory goal upon which risk assessments and risk management decisions are based.

How it is Measured or Detected

Population trajectories, either hypothetical or site specific, can be estimated via population modeling based on measurements of vital rates or reasonable surrogates measured in laboratory studies. As an example, Miller and Ankley 2004 used measures of cumulative fecundity from laboratory studies with repeat spawning fish species to predict population-level consequences of continuous exposure.

Evidence Supporting Taxonomic Applicability

Consideration of population size and changes in population size over time is potentially relevant to all living organisms.

Regulatory Examples Using This Adverse Outcome

Maintenance of sustainable fish and wildlife populations (i.e., adequate to ensure long-term delivery of valued ecosystem services) is a widely accepted regulatory goal upon which risk assessments and risk management decisions are based.

References

  • Miller DH, Ankley GT. 2004. Modeling impacts on populations: fathead minnow (Pimephales promelas) exposure to the endocrine disruptor 17trenbolone as a case study. Ecotoxicology and Environmental Safety 59: 1-9.