Event:444

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Event Title

Atrioventricular block and bradycardia, Increased
Short name: Atrioventricular block and bradycardia, Increased

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Acetylcholinesterase inhibition leading to acute mortality KE Weak
Sodium channel inhibition leading to congenital malformations KE

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

The rhythm of conduction between the atria and ventricles of the heart regulate heart rate. Disruption of heart rhythm can lead to reduced heart rate.

How it is Measured or Detected

Atrioventricular block and heart rate can be measured with an electrocardiogram (ECG).

Evidence Supporting Taxonomic Applicability

This key event is only relevant to organisms with a heart.

References