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Event Title

Mitochondrial fatty acid beta-oxidation, Inhibition

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
AhR activation leading to hepatic steatosis KE Strong
NR1I3 (CAR) suppression leading to hepatic steatosis KE
NFE2L2/FXR activation leading to hepatic steatosis KE

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability