Event:476

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Event Title

Hepatic FA, Accumulation
Hepatic FA, Accumulation

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis KE Strong

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

References