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Event Title

Ca++ ATPase, Inhibition
Short name: Ca++ ATPase, Inhibition

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Calcium-mediated neuronal ROS production and energy imbalance MIE

Chemical Initiators

The following are chemical initiators that operate directly through this Event:

  1. Lead(II)

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

Pb(II) has been shown to decrease Ca++ ATPase activity, leading to an increase in intracellular calcium. It is not known exactly how this works; however, it may be through Pb++ competition with Ca++ [1]

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability


  1. He, T, et al. 2009. Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae. NeuroToxicology 30(5): 777-84.