Event:585

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Event Title

Sodium conductance, decreased

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Sodium channel inhibition leading to reduced survival KE Moderate
sodium channel inhibition leading to increased predation KE Strong
Sodium channel inhibition leading to congenital malformations KE Strong
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival KE Moderate

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization
Cellular

How this Key Event works

The quick rise and fall of an electrical membrane potential of a cell, known as an action potential, is either diminished or eliminated.

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

Action potentials are found throughout multicellular organisms (plants, invertebrates, and vertebrates). Sponges are multicellular eukaryotes that do not transmit action potentials.

References