Event:619

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Event Title

5-hydroxytryptamine transporter (5-HTT; SERT) Inhibition

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline MIE
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation MIE
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase MIE Strong

Chemical Initiators

The following are chemical initiators that operate directly through this Event:

  1. Fluoxetine
  2. Fluvoxamine

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization
Molecular

How this Key Event works

Inhibitors of the serotonin reuptake transporter (SERT; 5-hydroxytryptamine transporter; 5-HTT) block the reuptake of the neurotransmitter serotonin, increasing its residence time in synapses.

How it is Measured or Detected

Toxcast assays that target the serotonin transporter (5-HTT; SERT) gene SLC6A4 include: NVS_TR_rSERT,NVS_TR_rSERT.

Evidence Supporting Taxonomic Applicability

References