Key Event Overview
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AOPs Including This Key Event
The following are chemical initiators that operate directly through this Event:
Level of Biological Organization
How this Key Event works
Inhibitors of the serotonin reuptake transporter (SERT; 5-hydroxytryptamine transporter; 5-HTT) block the reuptake of the neurotransmitter serotonin, increasing its residence time in synapses.
How it is Measured or Detected
Toxcast assays that target the serotonin transporter (5-HTT; SERT) gene SLC6A4 include: NVS_TR_rSERT,NVS_TR_rSERT.