Event:714

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Event Title

Binding of chemicals to 2u (serum), Increased
Binding of chemicals to 2u (serum), Increased

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) MIE

Chemical Initiators

The following are chemical initiators that operate directly through this Event:

  1. D-limonene
  2. Hydrocarbons, various

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

References