- 1 Event Title
- 2 Key Event Overview
- 3 How this Key Event works
- 4 How it is Measured or Detected
- 5 Evidence Supporting Taxonomic Applicability
- 6 Regulatory Examples Using This Adverse Outcome
- 7 References
Key Event Overview
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AOPs Including This Key Event
Level of Biological Organization
How this Key Event works
Spawning refers to the release of eggs. Cumulative fecundity refers to the total number of eggs deposited by a female, or group of females over a specified period of time.
How it is Measured or Detected
In laboratory-based reproduction assays (e.g., OECD 229; OECD 240), spawning and cumulative fecundity can be directly measured through daily observation of egg deposition and egg counts.
Evidence Supporting Taxonomic Applicability
Cumulative fecundity and spawning can, in theory, be evaluated for any egg laying animal.
Regulatory Examples Using This Adverse Outcome
Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. The OECD 229 assay serves as screening assay for endocrine disruption and associated reproductive impairment (OECD 2012). Fecundity is also an important apical endpoint in the Medaka Extended One Generation Reproduction Test (MEOGRT; OECD Test Guideline 240).
- OECD. 2012a. Test no. 229: Fish short term reproduction assay. Paris, France:Organization for Economic Cooperation and Development.